Sync up a bitcoin node using a portable 1 terabyte HDD?

Hey guys, I appreciate all the help from the Reddit community so far.

Regarding synchronization of the a Bitcoin node on on to my desktop, so far I'm 50% synced up, its been going for 2 days now and this is just the 2gb version (Pruning Mode, version 23.0). I have 50mbps internet connection.

Once this synchronization has been completed in another 2 days will I be able to sync up again but this time using a portable 1 terabyte HDD?

Thanks Guys.